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Adapting and Remolding: Orchestrating Tumor Microenvironment Normalization with Photodynamic Therapy by Size Transformable Nanoframeworks
Author(s) -
Liang Tingxizi,
Zhang Benhua,
Xing Zejing,
Dong Yuxiang,
Xu Hongmei,
Chen Xueqin,
Jiang Liping,
Zhu JunJie,
Min Qianhao
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202102180
Subject(s) - photodynamic therapy , tumor microenvironment , stroma , cancer research , metastasis , tumor hypoxia , hypoxia (environmental) , matrix metalloproteinase , photosensitizer , medicine , chemistry , cancer , pathology , tumor cells , radiation therapy , oxygen , immunohistochemistry , organic chemistry
Abnormal tumor microenvironment (TME) facilitates tumor proliferation and metastasis and establishes physiological barriers for effective transport of therapeutics inside the tumor, posing great challenges for cancer treatment. We designed a core‐satellite size transformable nanoframework (denoted as T‐PFRT) that can synchronously adapt to and remold TME for augmenting photodynamic therapy to inhibit tumor growth and prevent tumor metastasis. Upon matrix metalloproteinase 2 (MMP2)‐responsive dissociation of the nanoframework in TME, the core structure loaded with TGFβ signaling pathway inhibitor and oxygen‐carrying hemoglobin aims to stroma remodeling and hypoxia relief, allowing photosensitizer‐encapsulated satellite particles to penetrate to deep‐seated tumor for oxygen‐fueled photodynamic therapy. T‐PFRT could overcome the stroma and hypoxia barriers for delivering therapeutics and gain excellent therapeutic outcomes in the treatment of primary and metastatic tumors.