Singlet Oxygen Generation in Dark‐Hypoxia by Catalytic Microenvironment‐Tailored Nanoreactors for NIR‐II Fluorescence‐Monitored Chemodynamic Therapy | Zendy

Chen Tao | Zendy; Hou Peidong | Zendy; Zhang Yafei | Zendy; Ao Rujiang | Zendy; Su Lichao | Zendy; Jiang Yifan | Zendy; Zhang Yuanli | Zendy; Cai Huilan | Zendy; Wang Jun | Zendy; Chen Qiushui | Zendy; Song Jibin | Zendy; Lin Lisen | Zendy; Yang Huanghao | Zendy; Chen Xiaoyuan | Zendy

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Singlet Oxygen Generation in Dark‐Hypoxia by Catalytic Microenvironment‐Tailored Nanoreactors for NIR‐II Fluorescence‐Monitored Chemodynamic Therapy

Author(s) -

Chen Tao,

Hou Peidong,

Zhang Yafei,

Ao Rujiang,

Su Lichao,

Jiang Yifan,

Zhang Yuanli,

Cai Huilan,

Wang Jun,

Chen Qiushui,

Song Jibin,

Lin Lisen,

Yang Huanghao,

Chen Xiaoyuan

Publication year - 2021

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.202102097

Subject(s) - singlet oxygen , nanoreactor , catalysis , chemistry , liposome , glutathione , chelation , tumor microenvironment , photodynamic therapy , fluorescence , tumor hypoxia , biophysics , reactive oxygen species , membrane , photochemistry , superoxide , oxygen , combinatorial chemistry , biochemistry , inorganic chemistry , organic chemistry , cancer research , tumor cells , medicine , radiation therapy , physics , quantum mechanics , biology , enzyme

Singlet oxygen ( 1 O 2 ) has a potent anticancer effect, but photosensitized generation of 1 O 2 is inhibited by tumor hypoxia and limited light penetration depth. Despite the potential of chemodynamic therapy (CDT) to circumvent these issues by exploration of 1 O 2 ‐producing catalysts, engineering efficient CDT agents is still a formidable challenge since most catalysts require specific pH to function and become inactivated upon chelation by glutathione (GSH). Herein, we present a catalytic microenvironment‐tailored nanoreactor (CMTN), constructed by encapsulating MoO 4 2− catalyst and alkaline sodium carbonate within liposomes, which offers a favorable pH condition for MoO 4 2− ‐catalyzed generation of 1 O 2 from H 2 O 2 and protects MoO 4 2− from GSH chelation owing to the impermeability of liposomal lipid membrane to ions and GSH. H 2 O 2 and 1 O 2 can freely cross the liposomal membrane, allowing CMTN with a built‐in NIR‐II ratiometric fluorescent 1 O 2 sensor to achieve monitored tumor CDT.

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