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Singlet Oxygen Generation in Dark‐Hypoxia by Catalytic Microenvironment‐Tailored Nanoreactors for NIR‐II Fluorescence‐Monitored Chemodynamic Therapy
Author(s) -
Chen Tao,
Hou Peidong,
Zhang Yafei,
Ao Rujiang,
Su Lichao,
Jiang Yifan,
Zhang Yuanli,
Cai Huilan,
Wang Jun,
Chen Qiushui,
Song Jibin,
Lin Lisen,
Yang Huanghao,
Chen Xiaoyuan
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202102097
Subject(s) - singlet oxygen , nanoreactor , catalysis , chemistry , liposome , glutathione , chelation , tumor microenvironment , photodynamic therapy , fluorescence , tumor hypoxia , biophysics , reactive oxygen species , membrane , photochemistry , superoxide , oxygen , combinatorial chemistry , biochemistry , inorganic chemistry , organic chemistry , cancer research , tumor cells , medicine , radiation therapy , physics , quantum mechanics , biology , enzyme
Singlet oxygen ( 1 O 2 ) has a potent anticancer effect, but photosensitized generation of 1 O 2 is inhibited by tumor hypoxia and limited light penetration depth. Despite the potential of chemodynamic therapy (CDT) to circumvent these issues by exploration of 1 O 2 ‐producing catalysts, engineering efficient CDT agents is still a formidable challenge since most catalysts require specific pH to function and become inactivated upon chelation by glutathione (GSH). Herein, we present a catalytic microenvironment‐tailored nanoreactor (CMTN), constructed by encapsulating MoO 4 2− catalyst and alkaline sodium carbonate within liposomes, which offers a favorable pH condition for MoO 4 2− ‐catalyzed generation of 1 O 2 from H 2 O 2 and protects MoO 4 2− from GSH chelation owing to the impermeability of liposomal lipid membrane to ions and GSH. H 2 O 2 and 1 O 2 can freely cross the liposomal membrane, allowing CMTN with a built‐in NIR‐II ratiometric fluorescent 1 O 2 sensor to achieve monitored tumor CDT.