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Recent Advances in Polymeric Nanoparticles for Enhanced Fluorescence and Photoacoustic Imaging
Author(s) -
Ong Sing Yee,
Zhang Changyu,
Dong Xiao,
Yao Shao Q.
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202101964
Subject(s) - photoacoustic imaging in biomedicine , nanotechnology , fluorescence , nanoparticle , materials science , polymer , fluorescence lifetime imaging microscopy , physics , quantum mechanics , optics , composite material
In recent years, polymeric nanoparticles (NPs) have become increasingly popular for in vitro and in vivo bioimaging because of their excellent versatility and exceptional optical properties. Following a brief introduction on fluorescence and photoacoustic imaging, as well as the merits of using polymeric NPs over other types of fluorescent probes, this Minireview gives a concise summary of key advances made in recent years (2017–2020) in the use of polymeric NPs for fluorescence and photoacoustic imaging. A particular focus is placed on various strategies used for enhanced bioimaging applications, including polymeric NPs that encapsulate near‐infrared dyes, aggregation‐induced‐emission fluorogens, cationic dyes doped with bulky hydrophobic counterions, and semiconducting polymers. Next, the current limitations in some of these polymeric NP systems are summarized and potential solutions offered to overcome them. Finally, some critical considerations in regard to the design of polymeric NPs are given for future bioimaging and sensing applications.