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Enantioselective α‐Carbonylative Arylation for Facile Construction of Chiral Spirocyclic β,β′‐Diketones
Author(s) -
Wu Ting,
Zhou Qinghai,
Tang Wenjun
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202101668
Subject(s) - enantioselective synthesis , nucleophile , chemistry , combinatorial chemistry , ring (chemistry) , catalysis , stereochemistry , organic chemistry
We herein describe the first enantioselective α‐carbonylative arylation, providing a diverse set of chiral spiro β,β′‐diketones bearing various ring sizes and functionalities in high yields and good to excellent enantioselectivities. Calculations suggest the transformation proceeds through reductive elimination instead of nucleophilic addition pathway.