Premium
A Cysteine‐Mediated Synthesis of Red Phosphorus Nanosheets
Author(s) -
Mo Jianbin,
Xu Yun,
Zhu Longqian,
Wei Wei,
Zhao Jing
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202101486
Subject(s) - phosphorus , nanomaterials , reagent , cysteine , nanotechnology , black phosphorus , reactive oxygen species , chemistry , materials science , combinatorial chemistry , biochemistry , organic chemistry , optoelectronics , enzyme
Among phosphorus‐based nanomaterials, layered black phosphorus and violet phosphorus have been actively explored in the past decade. However, methods for the synthesis of red phosphorus nanosheets (RPNSs) is lacking, even though red phosphorus (RP) is commercially available at low cost and has excellent chemical stability at room temperature. We report an efficient strategy for fabrication of RPNSs and doped RPNSs using cysteine as a reducing reagent. Data from in vitro and in vivo studies suggested that RPNSs can trigger production of reactive oxygen species, DNA damage, and subsequent autophagy‐mediated cell death in a shape‐dependent manner. Our findings provide a method for construction of layered RP nanomaterials and they present a unique mechanism for the application of phosphorus‐based materials in nanomedicines.