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Water‐Soluble Organic Nanoparticles with Programable Intermolecular Charge Transfer for NIR‐II Photothermal Anti‐Bacterial Therapy
Author(s) -
Tian Shuang,
Bai Haotian,
Li Shengliang,
Xiao Yafang,
Cui Xiao,
Li Xiaozhen,
Tan Jihua,
Huang Zhongming,
Shen Dong,
Liu Weimin,
Wang Pengfei,
Tang Ben Zhong,
Lee ChunSing
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202101406
Subject(s) - photothermal therapy , nanoparticle , absorption (acoustics) , perylene , materials science , intermolecular force , molecule , acceptor , small molecule , nanotechnology , near infrared spectroscopy , photochemistry , chemistry , organic chemistry , optics , biochemistry , physics , condensed matter physics , composite material
Extensive recent efforts have been put on the design of high‐performance organic near‐infrared (NIR) photothermal agents (PTAs), especially over NIR‐II bio‐window (1000–1350 nm). So far, the development is mainly limited by the rarity of molecules with good NIR‐II response. Here, we report organic nanoparticles of intermolecular charge‐transfer complexes (CTCs) with easily programmable optical absorption. By employing different common donor and acceptor molecules to form CTC nanoparticles (CT NPs), absorption peaks of CT NPs can be controllably tuned from the NIR‐I to NIR‐II region. Notably, CT NPs formed with perylene and TCNQ have a considerably red‐shifted absorption peak at 1040 nm and achieves a good photothermal conversion efficiency of 42 % under 1064 nm excitation. These nanoparticles were used for antibacterial application with effective activity towards both Gram‐negative and Gram‐positive bacteria. This work opens a new avenue into the development of efficient PTAs.