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Nanoparticle‐Stabilized Oxygen Microcapsules Prepared by Interfacial Polymerization for Enhanced Oxygen Delivery
Author(s) -
Wu Baiheng,
Sun Zhu,
Wu Jiangchao,
Ruan Jian,
Zhao Peng,
Liu Kai,
Zhao ChunXia,
Sheng Jianpeng,
Liang Tingbo,
Chen Dong
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202100752
Subject(s) - biocompatibility , tumor hypoxia , tumor microenvironment , oxygen , hypoxia (environmental) , chemistry , nanoparticle , polymerization , in vivo , biophysics , oxygen delivery , nanotechnology , materials science , tumor cells , cancer research , polymer , organic chemistry , medicine , surgery , radiation therapy , biology , microbiology and biotechnology
Most tumors have more severe hypoxia levels than normal tissue; tumor hypoxia is thus a useful target for cancer treatment. Here, we develop an effective oxygen delivery vehicle of polydopamine‐nanoparticle‐stabilized oxygen microcapsules by interfacial polymerization. The oxygen microcapsules have excellent biocompatibility. Oxygen could easily diffuse out from the microcapsules, thus increasing and maintaining the microenvironment at an oxygen‐rich state. In vitro cell cultures confirm that oxygen microcapsules could effectively improve the hypoxia microenvironment, showing the lowest fluorescent intensity of hypoxia‐green‐labeled cells. When injected subcutaneously in vivo, oxygen microcapsules could also improve the tumor's hypoxia microenvironment, thus suppressing the growth of tumor. Synergetic therapy using oxygen microcapsules and gemcitabine drugs is an effective way for tumor treatment, showing the best performance in suppressing the tumor's growth.