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In Vivo X‐ray Triggered Catalysis of H 2 Generation for Cancer Synergistic Gas Radiotherapy
Author(s) -
Wu Ying,
Su Lichao,
Yuan Meng,
Chen Tao,
Ye Jiamin,
Jiang Yifan,
Song Jibin,
Yang Huanghao
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202100002
Subject(s) - radiation therapy , in vivo , materials science , cancer , photocatalysis , amorphous solid , cancer research , x ray , nanotechnology , catalysis , chemistry , medicine , crystallography , biochemistry , optics , biology , microbiology and biotechnology , physics
To date, hydrogen (H 2 ) therapy has received widespread attention. However, X‐ray triggered sustainable H 2 ‐producing materials with controlled release for cancer treatment have not been reported. Herein, an X‐ray triggered sustainable in situ H 2 producing platform, Au NR‐TiO 2 @ZnS:Cu,Co‐A(Au‐TiO 2 @ZnS), composed of Au‐amorphous TiO 2 nano‐dumbbell‐shaped heterostructure coated with long afterglow particles, was developed for cancer synergistic H 2 ‐radiotherapy. The mechanism of H 2 production was verified by theoretical calculations and in vitro experiments. Changes in the apoptosis pathway caused by the synergistic effect of H 2 and radiotherapy were reported. Guided by its excellent photoacoustic imaging capabilities, mice with orthotopic liver cancer achieved excellent therapeutic effects and low inflammatory side effects, suggesting that Au‐TiO 2 @ZnS has promising application potential for cancer treatment and prognosis.