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Frontispiece: 3‐ O ‐Sulfation of Heparan Sulfate Enhances Tau Interaction and Cellular Uptake
Author(s) -
Zhao Jing,
Zhu Yanan,
Song Xuehong,
Xiao Yuanyuan,
Su Guowei,
Liu Xinyue,
Wang Zhangjie,
Xu Yongmei,
Liu Jian,
Eliezer David,
Ramlall Trudy F.,
Lippens Guy,
Gibson James,
Zhang Fuming,
Linhardt Robert J.,
Wang Lianchun,
Wang Chunyu
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202080561
Subject(s) - sulfation , heparan sulfate , chemistry , sulfate , biochemistry , biophysics , microbiology and biotechnology , glycosaminoglycan , biology , organic chemistry
Proteins L. Wang, C. Wang, and co‐workers report in their Research Article on page 1818 how a rare 3‐ O ‐sulfation of heparan sulfate significantly enhances tau binding and cellular uptake of tau, thus providing a novel target for treating Alzheimer′s disease.