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Multicomponent Self‐Assembly of a Giant Heterometallic Polyoxotungstate Supercluster with Antitumor Activity
Author(s) -
Liu JianCai,
Wang JieFei,
Han Qing,
Shangguan Ping,
Liu LuLu,
Chen LiJuan,
Zhao JunWei,
Streb Carsten,
Song YuFei
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202017318
Subject(s) - chemistry , superstructure , in vivo , linkage (software) , stereochemistry , biochemistry , biology , physics , gene , microbiology and biotechnology , thermodynamics
The hierarchical aggregation of molecular nanostructures from multiple components is a grand synthetic challenge, which requires highly selective linkage control. We demonstrate how two orthogonal linkage groups, that is, organotin and lanthanide cations, can be used to drive the aggregation of a giant molecular metal oxide superstructure. The title compound {[(Sn(CH 3 ) 2 ) 2 O] 4 {[CeW 5 O 18 ] [TeW 4 O 16 ][CeSn(CH 3 ) 2 ] 4 [TeW 8 O 31 ] 4 } 2 } 46− ( 1 a ) features dimensions of ca. 2.2×2.3×3.4 nm 3 and a molecular weight of ca. 25 kDa. Structural analysis shows the hierarchical aggregation from several independent subunits. Initial biomedical tests show that 1 features an inhibitory effect on the proliferation of HeLa cells based on an apoptosis pathway. In vivo experiments in mice reveal the antiproliferative activity of 1 and open new paths for further development of this new compound class.