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Iodide‐Mediated Rapid and Sensitive Surface Etching of Gold Nanostars for Biosensing
Author(s) -
Xianyu Yunlei,
Lin Yiyang,
Chen Qu,
BelessiotisRichards Alexis,
Stevens Molly M.,
Thomas Michael R.
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202017317
Subject(s) - surface plasmon resonance , etching (microfabrication) , biosensor , nanotechnology , colloidal gold , nanoparticle , iodide , materials science , plasmon , surface modification , surface plasmon , chemistry , optoelectronics , inorganic chemistry , layer (electronics)
Iodide‐mediated surface etching can tailor the surface plasmon resonance of gold nanostars through etching of the high‐energy facets of the nanoparticle protrusions in a rapid and sensitive way. By exploring the underlying mechanisms of this etching and the key parameters influencing it (such as iodide, oxygen, pH, and temperature), we show its potential in a sensitive biosensing system. Horseradish peroxidase‐catalyzed oxidation of iodide enables control of the etching of gold nanostars to spherical gold nanoparticles, where the resulting spectral shift in the surface plasmon resonance yields a distinct color change of the solution. We further develop this enzyme‐modulated surface etching of gold nanostars into a versatile platform for plasmonic immunoassays, where a high sensitivity is possible by signal amplification via magnetic beads and click chemistry.