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Deciphering the Supramolecular Organization of Multiple Guests Inside a Microporous MOF to Understand their Release Profile
Author(s) -
Balestri Davide,
Mazzeo Paolo P.,
Perrone Roberto,
Fornari Fabio,
Bianchi Federica,
Careri Maria,
Bacchi Alessia,
Pelagatti Paolo
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202017105
Subject(s) - microporous material , supramolecular chemistry , single crystal , molecule , metal organic framework , chemistry , chemical engineering , thymol , solvent , crystal engineering , nanotechnology , materials science , organic chemistry , crystallography , adsorption , chromatography , essential oil , engineering
Metal‐organic frameworks (MOFs) give the opportunity of confining guest molecules into their pores even by a post‐synthetic protocol. PUM168 is a Zn‐based MOF characterized by microporous cavities that allows the encapsulation of a significant number of guest molecules. The pores engineered with different binding sites show a remarkable guest affinity towards a series of natural essential oils components, such as eugenol, thymol and carvacrol, relevant for environmental applications. Exploiting single crystal X‐ray diffraction, it was possible to step‐wisely monitor the rather complex three‐components guest exchange process involving dimethylformamide (DMF, the pristine solvent) and binary mixtures of the flavoring agents. A picture of the structural evolution of the DMF‐to‐guest replacement occurring inside the MOF crystal was reached by a detailed single‐crystal‐to‐single‐crystal monitoring. The relation of the supramolecular arrangement in the pores with selective guests release was then investigated as a function of time and temperature by static headspace GC‐MS analysis.