Photo‐Controllable Catalysis and Chiral Monosaccharide Recognition Induced by Cyclodextrin Derivatives

A supramolecular catalytic system was constructed from polycationic α‐cyclodextrin ( 6‐Iz‐α‐CD ) and gold nanoparticles ( AuNP ) using a supramolecular assembly strategy. The cavity of cyclodextrin is the channel by which the substrate molecules come into contact with the catalytic center. Introduction of the azobenzene‐modified diphenylalanine ( Azo‐FF ) guest molecule allowed for precise photo‐control of the catalytic activity owing to its sensitive response to irradiation. Importantly, as a unique glucose oxidase the AuNP@6‐Iz‐α‐CD realizes unprecedented chiral recognition catalysis for chiral monosaccharides. In combination with a 3,3′,5,5′‐tetramethylbenzidine (TMB) color reaction, AuNP@6‐Iz‐α‐CD is able to recognize the chirality of various monosaccharides.