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Cover Picture: Furin‐Mediated Self‐Assembly of Olsalazine Nanoparticles for Targeted Raman Imaging of Tumors (Angew. Chem. Int. Ed. 8/2021)
Author(s) -
Yuan Yue,
Raj Piyush,
Zhang Jia,
Siddhanta Soumik,
Barman Ishan,
Bulte Jeff W. M.
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202016964
Subject(s) - raman spectroscopy , raman scattering , in vivo , nanoparticle , in vitro , click chemistry , biophysics , nanotechnology , intracellular , materials science , furin , stacking , raman microspectroscopy , chemistry , enzyme , biochemistry , biology , polymer chemistry , optics , physics , microbiology and biotechnology , organic chemistry
Single olsalazine molecules can be self‐assembled into nanoparticles by the tumor‐overexpressed enzyme furin following a 2‐cyanobenzothiazole (CBT)‐mediated biocompatible click condensation reaction and π–π stacking, as demonstrated by Ishan Barman, Jeff W. M. Bulte et al. in their Communication on page 3923. These intracellular nanoparticles provide a differential Raman scattering signature, allowing highly specific imaging of cancer cells in vitro and in vivo.