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Inside Cover: Chemistry of Tertiary Carbon Center in the Formation of Congested C−O Ether Bonds (Angew. Chem. Int. Ed. 8/2021)
Author(s) -
Hirata Goki,
Takeuchi Kentarou,
Shimoharai Yusuke,
Sumimoto Michinori,
Kaizawa Hazuki,
Nokami Toshiki,
Koike Takashi,
Abe Manabu,
Shirakawa Eiji,
Nishikata Takashi
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202016909
Subject(s) - chemistry , alkyl , nucleophilic substitution , ether , tertiary amine , center (category theory) , medicinal chemistry , substitution (logic) , stereochemistry , organic chemistry , crystallography , computer science , programming language
A stereospecific nucleophilic substitution between tertiary alkyl bromides and tertiary alkyl alcohols is described in the Research Article on page 4329 by Toshiki Nokami, Takashi Koike, Manabu Abe, Eiji Shirakawa, Takashi Nishikata, and co‐workers. The entering alcohol formally attacks the C−Br bond to undergo a retentive substitution with formation of tertiary alkyl ethers.