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Recent Advances in Photoredox‐Mediated Radical Conjugate Addition Reactions: An Expanding Toolkit for the Giese Reaction
Author(s) -
Gant Kanegusuku Anastasia L.,
Roizen Jennifer L.
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202016666
Subject(s) - conjugate , radical , chemistry , photoredox catalysis , photochemistry , combinatorial chemistry , organic chemistry , catalysis , photocatalysis , mathematics , mathematical analysis
Photomediated Giese reactions are at the forefront of radical chemistry, much like the classical tin‐mediated Giese reactions were nearly forty years ago. With the global recognition of organometallic photocatalysts for the mild and tunable generation of carbon‐centered radicals, chemists have developed a torrent of strategies to form previously inaccessible radical intermediates that are capable of engaging in intermolecular conjugate addition reactions. This Review summarizes advances in photoredox‐mediated Giese reactions since 2013, with a focus on the breadth of methods that provide access to crucial carbon‐centered radical intermediates that can engage in radical conjugate addition processes.