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Silver‐Catalysed Hydroarylation of Highly Substituted Styrenes
Author(s) -
Dalton Toryn,
Greßies Steffen,
Das Mowpriya,
Niehues Maximilian,
Schrader Malte L.,
Gutheil Christian,
Ravoo Bart Jan,
Glorius Frank
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202016268
Subject(s) - alkene , nucleophile , reagent , chemistry , benzene , catalysis , combinatorial chemistry , organic chemistry
Hydroarylation is an effective strategy to rapidly increase the complexity of organic structures by transforming flat alkene moieties into three‐dimensional frameworks. Many strategies have already been developed to achieve the hydroarylation of styrenes, however most of these reports examine the hydroarylation of unpolar, β‐mono‐ or β‐unsubstituted styrenes, while exploring mainly electron‐rich benzene nucleophiles. Herein, we report a mild and general catalytic system for the selective hydroheteroarylation of multiply substituted styrenes and heteroaromatic styrenes. Mechanistic analysis of the reaction led to the discovery of commercially available 2,2′:5′,2′′‐terthiophene as a key reagent.