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Metal‐Coordinated Supramolecular Polymers from the Minimalistic Hybrid Peptide Foldamers
Author(s) -
Dey Sanjit,
Misra Rajkumar,
Saseendran Abhijith,
Pahan Saikat,
Gopi Hosahudya N.
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202015838
Subject(s) - tripeptide , steric effects , foldamer , supramolecular chemistry , crystallography , chemistry , polymerization , peptide , polyproline helix , helix (gastropod) , polymer , metal ions in aqueous solution , metal , pyridine , stereochemistry , crystal structure , organic chemistry , biochemistry , ecology , snail , biology
Abstract Availing the peptide folded architectures to design metal‐coordinated frameworks and cages is restricted due to the scarcity of readily accessible short and stable secondary structures. The secondary structures, α‐helix and β‐sheets, play significant roles in stabilizing tertiary folds of proteins. Designing such helical structures from the short sequences of peptides without having any steric restrictions is exceptionally challenging. Here we reveal the short α,γ‐hybrid tripeptide sequences that manifest stable helical structures without having any sterically constrained amino acids. These short hybrid tripeptides fold into helices even in the presence of two typically β‐sheet favoring Val residues. The hybrid helix consisting of terminal pyridine units coordinates with the metal ions and drives the helical polymerization. Depending on the sequence and the position of N in pyridine moieties, these peptides form selective metallogels with Ag + and Cu 2+ ions. The X‐ray diffracted analysis of the peptide single crystals obtained from the gel matrix reveals that the helical structure is maintained during the self‐assembly process. Further, by varying the counter anion, a 3D helical crystalline coordination polymer with permanent porosity is generated. The findings reported here can be used to design new functional metal‐foldamer coordinated polymers.