Premium
Inside Back Cover: Synthesis of a Pentasaccharide Repeating Unit of Lipopolysaccharide Derived from Virulent E. coli O1 and Identification of a Glycotope Candidate of Avian Pathogenic E. coli O1 (Angew. Chem. Int. Ed. 4/2021)
Author(s) -
Nishi Nobuya,
Seki Katsunori,
Takahashi Daisuke,
Toshima Kazunobu
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202015610
Subject(s) - virulence , pathogenic escherichia coli , microbiology and biotechnology , pathogenic bacteria , escherichia coli , identification (biology) , biology , bacteria , gene , genetics , botany
Identification of the glycotope of avian pathogenic E. coli (APEC) O1 is important for the design of a new generation of improved and safer vaccines. In their Research Article on page 1789, Daisuke Takahashi, Kazunobu Toshima, and co‐workers synthesize the unique pentasaccharide derived from virulent E. coli O1 and reveal that the pentasaccharide is a glycotope candidate of APEC O1, with great potential as an antigen for vaccine development.