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Decarboxylative Polyfluoroarylation of Alkylcarboxylic Acids
Author(s) -
Sun Xiang,
Ritter Tobias
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202015596
Subject(s) - decarboxylation , scope (computer science) , substrate (aquarium) , chemistry , combinatorial chemistry , functional group , small molecule , organic chemistry , computer science , biology , catalysis , biochemistry , ecology , polymer , programming language
Polyfluoroarenes are useful building blocks in several areas such as drug discovery, materials, and crop protection. Herein, we report the first polyfluoroarylation of aliphatic carboxylic acids via photoredox decarboxylation. The method proceeds with broad substrate scope and high functional group tolerance. Moreover, small complex molecules such as natural products and drugs can be modified by late‐stage modification.