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Quantitative Mapping of Glutathione within Intracranial Tumors through Interlocked MRI Signals of a Responsive Nanoprobe
Author(s) -
Zhang Peisen,
Zeng Jianfeng,
Li Yingying,
Yang Chen,
Meng Junli,
Hou Yi,
Gao Mingyuan
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202014348
Subject(s) - nanoprobe , in vivo , glutathione , magnetic resonance imaging , glioma , chemistry , pathology , nuclear magnetic resonance , materials science , nanoparticle , radiology , cancer research , medicine , nanotechnology , biology , biochemistry , physics , microbiology and biotechnology , enzyme
Studies reveal that malignant tumors feature uneven distributions of some key biomarkers across the entire tumorous region. Nevertheless, only very limited progress has been made towards non‐invasive and quantitative detection of tumor‐specific biomarkers in vivo, especially with clinically compatible imaging modalities. Reported here is an Fe 3 O 4 nanoparticle‐based glutathione (GSH) responsive magnetic resonance imaging (MRI) probe that can form particle aggregates within tumors in vivo to give rise to strong GSH concentration dependent interlocked relaxivities. A quantitative correlation between the interlocked MRI signals and local GSH concentration was established, and further applied for mapping the heterogeneous distribution of GSH within an intracranial tumor (2.4 mm × 1.6 mm) in vivo. This methodology will offer a practical route for quantitatively mapping tumor‐specific biomarkers in vivo with unlimited detection depth, which largely challenges optical‐imaging‐based approaches.