Convergent Total Synthesis of Yaku'amide A

Total synthesis of the anticancer peptide natural product yaku'amide A is reported. Its β‐ tert ‐hydroxy amino acids were prepared by regioselective aminohydroxylation involving a chiral mesyloxycarbamate reagent. Stereospecific construction of the E ‐ and Z ‐ΔIle residues was accomplished through a one‐pot reaction featuring anti dehydration, azide reduction, and O→N acyl transfer. Alkene isomerization was negligible during this process. These methods enabled a highly convergent and efficient synthetic route to the natural product.