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On‐POM Ring‐Opening Polymerisation of N ‐Carboxyanhydrides
Author(s) -
SoriaCarrera Héctor,
FrancoCastillo Isabel,
Romero Pilar,
Martín Santiago,
Fuente Jesús M.,
Mitchell Scott G.,
MartínRapún Rafael
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202013563
Subject(s) - polymerization , chemistry , combinatorial chemistry , oxide , amino acid , ring (chemistry) , ring opening polymerization , scaffold , polymer chemistry , hybrid material , polymer , organic chemistry , biochemistry , computer science , database
The ring‐opening polymerisation of α‐amino acid N ‐carboxyanhydrides (NCAs) offers a simple and scalable route to polypeptides with predicted and narrow molecular weight distributions. Here we show how polyoxometalates (POMs)—redox‐active molecular metal‐oxide anions—can serve as inorganic scaffold initiators for such NCA polymerisations. This “On‐POM polymerisation” strategy serves as an innovative platform to design hybrid materials with additive or synergistic properties stemming from the inorganic and polypeptide component parts. We have used this synthetic approach to synthesise a library of bactericidal poly(lysine)–POM hybrid derivatives that can be used to prevent biofilm formation. This versatile “On‐POM polymerisation” method provides a flexible synthetic approach for combining inorganic scaffolds with amino acids, and the potential to tailor and improve the specificity and performance of hybrid antimicrobial materials.