Premium
Heterocyclization Reagents for Rapid Assembly of N‐Fused Heteroarenes from Alkenes
Author(s) -
Zhang Huihui,
Wang Min,
Wu Xinxin,
Zhu Chen
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202013089
Subject(s) - reagent , combinatorial chemistry , cascade , chemistry , compatibility (geochemistry) , functional group , computer science , organic chemistry , engineering , chromatography , chemical engineering , polymer
Abstract N‐Fused heterocycles are of particular use and upmost importance in multiple fields. Herein, we disclose a conceptually new approach for the rapid assembly of N‐fused heteroarenes from alkenes. A portfolio of strategically designed heterocyclization reagents are readily prepared for the cascade reaction. A plethora of N‐fused heteroarenes including seven types of heterocyclic core are furnished. The protocol features a broad functional‐group compatibility and high product diversity, and provides a practical tool for late‐stage heteroarene elaboration.