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Going Platinum to the Tune of a Remarkable Guanine Quadruplex Binder: Solution‐ and Solid‐State Investigations.
Author(s) -
Miron Caitlin E.,
Staalduinen Laura,
Rangaswamy Alana M.,
Chen Mickey,
Liang Yushi,
Jia Zongchao,
Mergny JeanLouis,
Petitjean Anne
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202012520
Subject(s) - guanine , g quadruplex , platinum , nucleic acid , solid state , ligand (biochemistry) , chemistry , combinatorial chemistry , duplex (building) , dna , selectivity , nanotechnology , stereochemistry , materials science , biochemistry , nucleotide , catalysis , receptor , gene
Guanine quadruplex recognition has gained increasing attention, inspired by the growing awareness of the key roles played by these non‐canonical nucleic acid architectures in cellular regulatory processes. We report here the solution and solid‐state studies of a novel planar platinum(II) complex that is easily assembled from a simple ligand, and exhibits notable binding affinity for guanine quadruplex structures, while maintaining good selectivity for guanine quadruplex over duplex structures. A crystal structure of this ligand complexed with a telomeric quadruplex confirms double end‐capping, with dimerization at the 5′ interface.