Premium
Back Cover: Aptamers with Tunable Affinity Enable Single‐Molecule Tracking and Localization of Membrane Receptors on Living Cancer Cells (Angew. Chem. Int. Ed. 42/2020)
Author(s) -
Delcanale Pietro,
Porciani David,
Pujals Silvia,
Jurkevich Alexander,
Chetrusca Andrian,
Tawiah Kwaku D.,
Burke Donald H.,
Albertazzi Lorenzo
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202012277
Subject(s) - aptamer , cover (algebra) , receptor , chemistry , molecule , membrane , resolution (logic) , biophysics , cancer cell , nanotechnology , tracking (education) , cell membrane , microscopy , materials science , cancer , biochemistry , microbiology and biotechnology , biology , physics , computer science , mechanical engineering , psychology , pedagogy , organic chemistry , engineering , genetics , optics , artificial intelligence
Rational engineering of low‐affinity aptamers expands the toolkit of affinity probes for super‐resolution microscopy. In their Research Article on page 18546, D. H. Burke, L. Albertazzi, and co‐workers demonstrate that a low‐affinity aptamer targeting cell‐surface EGFR allows for simultaneous single‐molecule tracking and single‐molecule localization microscopy of individual receptors at high labeling density to define spatiotemporal dynamics on living and unperturbed cancer cells. Cover picture: Bri Ebenroth.