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Cobalt‐Catalyzed Markovnikov‐Type Selective Hydroboration of Terminal Alkynes
Author(s) -
Chen Jieping,
Shen Xuzhong,
Lu Zhan
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202012164
Subject(s) - markovnikov's rule , hydroboration , alkene , chemistry , regioselectivity , catalysis , cobalt , combinatorial chemistry , ligand (biochemistry) , hydride , terminal (telecommunication) , organic chemistry , medicinal chemistry , metal , biochemistry , receptor , telecommunications , computer science
A cobalt‐catalyzed Markovnikov‐type hydroboration of terminal alkynes with HBpin to access α‐alkenyl boronates with good regioselectivity and atom economy is reported. A new ligand has been developed for the cobalt hydride catalyst that has been used for a unique Markovnikov selective insertion of terminal alkynes into metal hydride bond. This operationally simple protocol exhibits excellent functional group tolerance to deliver valuable alkene derivatives.