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A Photoregulated Racemase Mimic
Author(s) -
Saha Monochura,
Hossain Munshi Sahid,
Bandyopadhyay Subhajit
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202012124
Subject(s) - racemization , chemistry , cofactor , stereochemistry , deprotonation , pyridoxal phosphate , pyridoxal , serine , biochemistry , enzyme , organic chemistry , ion
The racemase enzymes convert L ‐amino acids to their D ‐isomer. The reaction proceeds through a stepwise deprotonation–reprotonation mechanism that is assisted by a pyridoxal phosphate (PLP) coenzyme. This work reports a PLP–photoswitch–imidazole triad where the racemization reaction can be controlled by light by tweaking the distance between the basic residue and the reaction centre.