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Back Cover: Membrane Chemistry Tunes the Structure of a Peptide Transporter (Angew. Chem. Int. Ed. 43/2020)
Author(s) -
LasitzaMale Tanya,
Bartels Kim,
Jungwirth Jakub,
Wiggers Felix,
Rosenblum Gabriel,
Hofmann Hagen,
Löw Christian
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202011870
Subject(s) - transporter , chemistry , peptide , biophysics , membrane , lipid bilayer , cover (algebra) , biochemistry , stereochemistry , biology , mechanical engineering , gene , engineering
Membrane transporters need to cycle through different conformations in order to perform function. Using state‐of‐the‐art smFRET tools, H. Hofmann, C. Löw, and co‐workers reveal in their Research Article on page 19121 that the dynamics and conformational variety of a peptide transporter is sensitively regulated by the lipid environment. Analyses in different lipid compositions highlight the influence of the lipid head group while artificial detergents trap the transporter in a single conformation.