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N‐Heterocyclic Carbene Catalyzed Ester Synthesis from Organic Halides through Incorporation of Oxygen Atoms from Air
Author(s) -
Tan Hui,
Wang ShenAn,
Yan Zixi,
Liu Jianzhong,
Wei Jialiang,
Song Song,
Jiao Ning
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202011039
Subject(s) - carbene , chemistry , catalysis , halide , oxygen , molecular oxygen , organic synthesis , combinatorial chemistry , oxidative phosphorylation , oxygen atom , photochemistry , organic chemistry , medicinal chemistry , molecule , biochemistry
Oxygenation reactions with molecular oxygen (O 2 ) as the oxygen source provides a green and straightforward strategy for the construction of O‐containing compounds. Demonstrated here is a novel N‐heterocyclic carbene (NHC) catalyzed oxidative transformation of simple and readily available organic halides into valuable esters through the incorporation of O‐atoms from O 2 . Mechanistic studies prove that the deoxy Breslow intermediate generated in situ is oxidized to a Breslow intermediate for further transformation by this oxidative protocol. This method broadens the field of NHC catalysis and promotes oxygenation reactions with O 2 .