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The Trojan Horse Goes Wild: The Effect of Drug Loading on the Behavior of Nanoparticles
Author(s) -
Stenzel Martina H.
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202010934
Subject(s) - trojan horse , nanomedicine , nanoparticle , drug delivery , drug , nanotechnology , trojan , chemistry , computer science , computer security , materials science , pharmacology , medicine
Drug delivery with nanoparticles is sometimes compared to an attack with a Trojan Horse. The drugs are hidden in nanoparticles and enter the unsuspecting cells in a stealth‐like fashion. Here, I would like to share my thoughts that a comparison to the Trojan Horse does not always apply, and provide examples where an increased drug loading content was detrimental to the drug‐delivery process. The purpose is to highlight the importance of understanding the physicochemical properties of nanoparticles, and the importance of having materials scientists in the line‐up of researchers working together to create successful nanomedicine.