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Modular Reconfigurable DNA Origami: From Two‐Dimensional to Three‐Dimensional Structures
Author(s) -
Liu Yan,
Cheng Jin,
Fan Sisi,
Ge Huan,
Luo Tao,
Tang Linlin,
Ji Bin,
Zhang Chuan,
Cui Daxiang,
Ke Yonggang,
Song Jie
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202010433
Subject(s) - dna origami , modular design , template , computer science , self reconfiguring modular robot , dna nanotechnology , nanotechnology , transformation (genetics) , modularity (biology) , dna , topology (electrical circuits) , nanostructure , engineering , materials science , artificial intelligence , chemistry , robot , biology , biochemistry , genetics , robot control , electrical engineering , gene , mobile robot , operating system
DNA origami enables the manipulation of objects at nanoscale, and demonstrates unprecedented versatility for fabricating both static and dynamic nanostructures. In this work, we introduce a new strategy for transferring modular reconfigurable DNA nanostructures from two‐dimensional to three‐dimensional. A 2D DNA sheet could be modularized into connected parts (e.g., two, three, and four parts in this work), which can be independently transformed between two conformations with a few DNA “trigger” strands. More interestingly, the transformation of the connected 2D modules can lead to the controlled, resettable structural conversion of a 2D sheet to a 3D architecture, due to the constraints induced by the connections between the 2D modules. This new approach can provide an efficient mean for constructing programmable, higher‐order, and complex DNA objects, as well as sophisticated dynamic substrates for various applications.