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Ultrasound Controlled Anti‐Inflammatory Polarization of Platelet Decorated Microglia for Targeted Ischemic Stroke Therapy
Author(s) -
Li Yujie,
Teng Xucong,
Yang Chunrong,
Wang Yongji,
Wang Lingxiao,
Dai Yicong,
Sun Hua,
Li Jinghong
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202010391
Subject(s) - microglia , medicine , inflammation , stroke (engine) , immune system , cancer research , immunology , mechanical engineering , engineering
Abstract Stroke is a lethal cerebral disease with severe sequelae and high mortality. Microglia, the main immune cell in the cerebrum, possess therapeutic potential for strokes as its specific anti‐inflammatory phenotype can reduce inflammation and promote neuron regeneration. However, the on‐demand anti‐inflammatory polarization of microglia at the stroke site is uncontrollable for therapeutic application. Here, we develop a platelet hybrid microglia platform which can specifically polarize to the anti‐inflammatory phenotype by ultrasound irradiation for targeted cerebrum repair after stroke. The engineered microglia have strong adherence to the injured cerebral vessels with platelet membrane fusion and realize on‐demand anti‐inflammatory polarization with ultrasound‐responsive IL‐4 liposome decoration. The intravenously injected microglia platform showed anti‐inflammatory polarization at the stroke site with insonation, and accelerated the M2‐type polarization of endogenous microglia for long‐term stroke recovery. Satisfied prognoses were achieved with reduced apoptosis, promoted neurogenesis, and functional recovery, indicating the implications of the microglia platform for stroke therapy.