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Enantio‐ and Regioselective NiH‐Catalyzed Reductive Hydroarylation of Vinylarenes with Aryl Iodides
Author(s) -
He Yuli,
Liu Chuang,
Yu Lei,
Zhu Shaolin
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202010386
Subject(s) - regioselectivity , chemistry , aryl , halide , catalysis , ligand (biochemistry) , combinatorial chemistry , reductive elimination , molecule , organic chemistry , receptor , alkyl , biochemistry
A highly enantio‐ and regioselective hydroarylation process of vinylarenes with aryl halides has been developed using a NiH catalyst and a new chiral bis imidazoline ligand. A broad range of structurally diverse, enantioenriched 1,1‐diarylalkanes, a structure found in a number of biologically active molecules, have been obtained with excellent yields and enantioselectivities under extremely mild conditions.