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Transition‐Metal‐Free Cross‐Coupling by Using Tertiary Benzylic Organoboronates
Author(s) -
Takeda Mitsutaka,
Nagao Kazunori,
Ohmiya Hirohisa
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202010251
Subject(s) - transition metal , coupling (piping) , chemistry , materials science , metallurgy , organic chemistry , catalysis
The transition‐metal‐free cross‐coupling of alkyl or aryl electrophiles by using tertiary benzylic organoboronates is reported. This reaction involves the generation of tertiary alkyl anions from organoboronates in the presence of an alkoxide base and then their substitution reactions. This protocol allows the simple and efficient construction of quaternary carbon centers.