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Inside Cover: Comprehensive and High‐Throughput Exploration of Chemical Space Using Broadband 19 F NMR‐Based Screening (Angew. Chem. Int. Ed. 35/2020)
Author(s) -
Lingel Andreas,
Vulpetti Anna,
Reinsperger Tony,
Proudfoot Andrew,
Denay Regis,
Frommlet Alexandra,
Henry Christelle,
Hommel Ulrich,
Gossert Alvar D.,
Luy Burkhard,
Frank Andreas O.
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202009848
Subject(s) - chemical space , cover (algebra) , fragment (logic) , broadband , throughput , ligand (biochemistry) , space (punctuation) , fluorine 19 nmr , chemical shift , combinatorial chemistry , materials science , chemistry , computer science , drug discovery , physics , nanotechnology , nuclear magnetic resonance spectroscopy , engineering , stereochemistry , nuclear magnetic resonance , optics , telecommunications , algorithm , mechanical engineering , biochemistry , receptor , wireless , operating system
19 F NMR‐based fragment screening is an effective approach in pharmaceutical research to explore the chemical space for specific target–ligand interactions. In their Research Article on page 14809, A. Lingel, A. O. Frank, and co‐workers report on the development of NMR pulses that cover the entire drug‐like fluorine chemical shift range in a single experiment. The new method allows for the efficient assembly of diverse fragment libraries that can be screened for high‐quality hits within a few days.