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A Tubular DNA Nanodevice as a siRNA/Chemo‐Drug Co‐delivery Vehicle for Combined Cancer Therapy
Author(s) -
Wang Zhaoran,
Song Linlin,
Liu Qing,
Tian Run,
Shang Yingxu,
Liu Fengsong,
Liu Shaoli,
Zhao Shuai,
Han Zihong,
Sun Jiashu,
Jiang Qiao,
Ding Baoquan
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202009842
Subject(s) - nanodevice , doxorubicin , dna , small interfering rna , chemistry , gene knockdown , rna interference , biophysics , rna , drug delivery , cancer research , nanotechnology , biochemistry , gene , materials science , biology , chemotherapy , genetics
Using the DNA origami technique, we constructed a DNA nanodevice functionalized with small interfering RNA (siRNA) within its inner cavity and the chemotherapeutic drug doxorubicin (DOX), intercalated in the DNA duplexes. The incorporation of disulfide bonds allows the triggered mechanical opening and release of siRNA in response to intracellular glutathione (GSH) in tumors to knockdown genes key to cancer progression. Combining RNA interference and chemotherapy, the nanodevice induced potent cytotoxicity and tumor growth inhibition, without observable systematic toxicity. Given its autonomous behavior, exceptional designability, potent antitumor activity and marked biocompatibility, this DNA nanodevice represents a promising strategy for precise drug design for cancer therapy.