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A Multifunctional Microfluidic Platform for High‐Throughput Experimentation of Electroorganic Chemistry
Author(s) -
Mo Yiming,
Rughoobur Girish,
Nambiar Anirudh M. K.,
Zhang Kara,
Jensen Klavs F.
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202009819
Subject(s) - microfluidics , modular design , nanotechnology , cyclic voltammetry , throughput , electrochemistry , electrode , anode , chemistry , materials science , combinatorial chemistry , computer science , telecommunications , wireless , operating system
Electroorganic synthesis is a promising tool to design sustainable transformations and discover new reactivities. However, the added setup complexity caused by electrodes in the system impedes efficient screening of reaction conditions. Herein, we present a microfluidic platform that enables automated high‐throughput experimentation (HTE) for electroorganic synthesis at a 15‐microliter scale. Two HTE modules are demonstrated: 1) the rapid electrochemical reaction condition screening for a radical–radical cross‐coupling reaction on micro‐fabricated interdigitated electrodes, and 2) measurements of kinetics for mediated anodic oxidations using the microliter‐scale cyclic voltammetry. The presented modular approach could be deployed for a range of other electroorganic chemistry applications beyond the demonstrated functionalities.