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Activity‐Based NIR Enzyme Fluorescent Probes for the Diagnosis of Tumors and Image‐Guided Surgery
Author(s) -
Li Haidong,
Kim Dayeh,
Yao Qichao,
Ge Haoying,
Chung Jeewon,
Fan Jiangli,
Wang Jingyun,
Peng Xiaojun,
Yoon Juyoung
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202009796
Subject(s) - fluorescence , carcinogenesis , malignant transformation , enzyme , transformation (genetics) , nanotechnology , computational biology , chemistry , cancer research , medicine , materials science , biology , gene , biochemistry , optics , physics
Near‐infrared (NIR) activatable fluorescent probes have been considered to be the effective edge tools for the investigation of cell biology and disease diagnosis because of their outstanding advantages. Related genes involved in tumor genesis and progression regulate the overexpression of certain enzymes. Owing to the distinctive characteristics of quick reaction time and favorable pharmacokinetics, enzyme‐reactive NIR optical probes have shown great potential in the diagnosis of tumorigenesis and in image‐guided intraoperative surgeries with high signal‐to‐noise ratios. In this review, we mainly summarize the latest advancements in enzyme‐reactive NIR fluorescent probes from design strategy to biomedical application. Specifically, some challenges and prospects in this field are presented at the end of the review, which will be beneficial to innovatively construct new multifunctional fluorescent probes and actively promote their clinical transformation in the future.