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Selective and Scalable Synthesis of Sugar Alcohols by Homogeneous Asymmetric Hydrogenation of Unprotected Ketoses
Author(s) -
Tindall Daniel J.,
Mader Steffen,
Kindler Alois,
Rominger Frank,
Hashmi A. Stephen K.,
Schaub Thomas
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202009790
Subject(s) - sugar , homogeneous , yield (engineering) , chemistry , organic chemistry , scalability , polymer , combinatorial chemistry , materials science , computer science , mathematics , database , combinatorics , metallurgy
Sugar alcohols are of great importance for the food industry and are promising building blocks for bio‐based polymers. Industrially, they are produced by heterogeneous hydrogenation of sugars with H 2 , usually with none to low stereoselectivities. Now, we present a homogeneous system based on commercially available components, which not only increases the overall yield, but also allows a wide range of unprotected ketoses to be diastereoselectively hydrogenated. Furthermore, the system is reliable on a multi‐gram scale allowing sugar alcohols to be isolated in large quantities at high atom economy.