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Ag + ‐Coupled Black Phosphorus Vesicles with Emerging NIR‐II Photoacoustic Imaging Performance for Cancer Immune‐Dynamic Therapy and Fast Wound Healing
Author(s) -
Li Zhi,
Fu Qinrui,
Ye Jiamin,
Ge Xiaoguang,
Wang Jie,
Song Jibin,
Yang Huanghao
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202009609
Subject(s) - photoacoustic imaging in biomedicine , photodynamic therapy , materials science , absorption (acoustics) , black phosphorus , cancer , near infrared spectroscopy , nanotechnology , chemistry , optoelectronics , optics , medicine , physics , organic chemistry , composite material
A silver‐ion‐coupled black phosphorus (BP) vesicle (BP Ve‐Ag + ) with a second near infrared (NIR‐II) window photoacoustic (PA) imaging capability was firstly constructed to maximize the potential of BP quantum dot (QD) in deeper bioimaging and diversified therapy. The embedded Ag + could improve the relatively large band gap of BP QD via intense charge coupling based on theoretical simulation results, subsequently leading to the enhanced optical absorption capability, accompanied with the occurrence of the strong NIR‐II PA signal. Guiding by NIR‐II PA bioimaging, the hidden Ag + could be precisely released with the disassembly of Ve during photodynamic therapy process and captured by macrophages located in lesion region for arousing synergistic cancer photodynamic/Ag + immunotherapy. BP Ve‐Ag + can contrapuntally kill pathogenic bacteria and accelerate wound healing monitored by NIR‐II PA imaging.