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Co‐Assembly between Fmoc Diphenylalanine and Diphenylalanine within a 3D Fibrous Viscous Network Confers Atypical Curvature and Branching
Author(s) -
Chakraborty Priyadarshi,
Tang Yiming,
Guterman Tom,
Ar Zohar A.,
Yao Yifei,
Wei Guanghong,
Gazit Ehud
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202009488
Subject(s) - branching (polymer chemistry) , supramolecular chemistry , self assembly , materials science , nanotechnology , curvature , peptide , nanostructure , crystallography , aqueous solution , chemistry , crystal structure , organic chemistry , geometry , composite material , biochemistry , mathematics
Supramolecular polymer co‐assembly is a useful approach to modulate peptide nanostructures. However, the co‐assembly scenario where one of the peptide building blocks simultaneously forms a hydrogel is yet to be studied. Herein, we investigate the co‐assembly formation of diphenylalanine (FF), and Fmoc‐diphenylalanine (FmocFF) within the 3D network of FmocFF hydrogel. The overlapping peptide sequence between the two building blocks leads to their co‐assembly within the gel state modulating the nature of the FF crystals. We observe the formation of branched microcrystalline aggregates with an atypical curvature, in contrast to the FF assemblies obtained from aqueous solution. Optical microscopy reveal the sigmoidal kinetic growth profile of these aggregates. Microfluidics and ToF‐SIMS experiments exhibit the presence of co‐assembled structures of FF and FmocFF in the crystalline aggregates. Molecular dynamics simulation was used to decipher the mechanism of co‐assembly formation.