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Cover Picture: Preparation of Functionalized Aryl, Heteroaryl, and Benzylic Potassium Organometallics Using Potassium Diisopropylamide in Continuous Flow (Angew. Chem. Int. Ed. 30/2020)
Author(s) -
Harenberg Johannes H.,
Weidmann Niels,
Knochel Paul
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202008426
Subject(s) - metalation , electrophile , chemistry , lithium diisopropylamide , potassium , aryl , flow chemistry , organic chemistry , medicinal chemistry , catalysis , ion , alkyl , deprotonation
Metalation of functionalized (hetero)arenes with KDA (potassium diisopropylamide)/TMEDA to give the corresponding potassium organometallics was performed using a commercial continuous flow set‐up. In their Communication on page 12321, P. Knochel et al. show that trapping with various electrophiles gives polyfunctionalized (hetero)aromatics in good yields. The flow procedure was extended to the lateral metalation of methyl‐substituted (hetero)arenes resulting in benzylic potassium organometallics, which were trapped with various electrophiles.