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Salivary Excretion of Renal‐Clearable Silver Nanoparticles
Author(s) -
Tang Shaoheng,
Huang Yingyu,
Zheng Jie
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202008416
Subject(s) - salivary gland , saliva , in vivo , chemistry , excretory system , submandibular gland , excretion , silver nanoparticle , colloidal gold , biochemistry , nanoparticle , endocrinology , biology , nanotechnology , materials science , microbiology and biotechnology
Salivary elimination is an important pathway for the body to excrete small molecules with digestive enzymes. However, very few engineered nanoparticles can be excreted through salivary glands, which often host bacteria or viruses during infection and involve in disease transmission. Herein, we report that renal clearable glutathione coated AgNPs (GS‐AgNPs) can selectively accumulate in the submandibular salivary gland, followed by being excreted in its excretory duct. By conducting head‐to‐head comparison on in vivo transport and interactions of both GS‐AgNPs and glutathione coated gold nanoparticles (GS‐AuNPs) with the same sizes, we found that low‐density GS‐AgNPs showed much higher vascular permeability than GS‐AuNPs and can rapidly penetrate into submandibular salivary glands, be efficiently taken up by striated and excretory duct cells, and eventually secreted into saliva.