Premium
Design and Synthesis of TY‐Phos and Application in Palladium‐Catalyzed Enantioselective Fluoroarylation of gem ‐Difluoroalkenes
Author(s) -
Lin TaoYan,
Pan Zhangjin,
Tu Youshao,
Zhu Shuai,
Wu HaiHong,
Liu Yu,
Li Zhiming,
Zhang Junliang
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202008262
Subject(s) - enantioselective synthesis , phosphine , combinatorial chemistry , phos , palladium , aryl , ligand (biochemistry) , chemistry , substrate (aquarium) , catalysis , organic chemistry , alkyl , biochemistry , receptor , oceanography , geology
The first example of highly enantioselective fluoroarylation of gem‐difluoroalkenes with aryl halides is presented by using a new chiral sulfinamide phosphine ( Sadphos ) type ligand TY‐Phos . N‐Me‐ TY‐Phos can be easily synthesized on a gram scale from readily available starting materials in three steps. Salient features of this work including readily available starting materials, good yields, high enantioselectivities as well as broad substrate scope make this approach very practical and attractive. Notably, the asymmetric synthesis of an analogue of a biologically active molecule is also reported.