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A Separation‐Sensing Membrane Performing Precise Real‐Time Serum Analysis During Blood Drawing
Author(s) -
Chu Zhenyu,
Zhang Wei,
You Qiannan,
Yao Xiaoyue,
Liu Tao,
Liu Gongping,
Zhang Guangru,
Gu Xiaoping,
Ma Zhengliang,
Jin Wanqin
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202008241
Subject(s) - nanoporous , biosensor , membrane , analyte , computer science , nanotechnology , chromatography , materials science , chemistry , biological system , biochemistry , biology
Dynamic and on‐site analysis of serum from human blood is crucial, however, state‐of‐the‐art blood‐assay methods can only collect single or discrete data of physiological analytes; thus, the online reports of the dynamic fluctuation of key analytes remains a great challenge. Here, we propose a novel separation‐sensing membrane by constructing a heterogeneous‐nanostructured architecture, wherein a surface nanoporous layer continuously extracts serum, while the biosensing nanochannels underneath dynamically recognise biotargets, thereby achieving a continuous testing of vital clinical indices as blood is drawn. By precisely controlling the pore structure and nanoshape of biosensing crystals, this membrane achieved accurate and online glucose and lactate monitoring in patients with a variety of medical conditions within 1 min, which is one order of magnitude faster than state‐of‐the‐art techniques. Moreover, various kinds of bio‐recognisers can be introduced into this membrane to accurately detect glutamate, transaminase, and cancer biomarkers.