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Supramolecular Assembly and Chirality of Synthetic Carbohydrate Materials
Author(s) -
Gim Soeun,
Fittolani Giulio,
Nishiyama Yoshiharu,
Seeberger Peter H.,
Ogawa Yu,
Delbianco Martina
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202008153
Subject(s) - supramolecular chemistry , disaccharide , carbohydrate , chirality (physics) , supramolecular chirality , crystal engineering , chemistry , enantiomer , nanotechnology , crystallography , crystal structure , stereochemistry , materials science , organic chemistry , nambu–jona lasinio model , chiral symmetry breaking , physics , quantum mechanics , quark
Hierarchical carbohydrate architectures serve multiple roles in nature. Hardly any correlations between the carbohydrate chemical structures and the material properties are available due to the lack of standards and suitable analytic techniques. Therefore, designer carbohydrate materials remain highly unexplored, as compared to peptides and nucleic acids. A synthetic D ‐glucose disaccharide, DD , was chosen as a model to explore carbohydrate materials. Microcrystal electron diffraction (MicroED), optimized for oligosaccharides, revealed that DD assembled into highly crystalline left‐handed helical fibers. The supramolecular architecture was correlated to the local crystal organization, allowing for the design of the enantiomeric right‐handed fibers, based on the L ‐glucose disaccharide, LL , or flat lamellae, based on the racemic mixture. Tunable morphologies and mechanical properties suggest the potential of carbohydrate materials for nanotechnology applications.