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Stereoinduction in Metallaphotoredox Catalysis
Author(s) -
Lipp Alexander,
Badir Shorouk O.,
Molander Gary A.
Publication year - 2021
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202007668
Subject(s) - catalysis , enantioselective synthesis , context (archaeology) , scope (computer science) , chemistry , combinatorial chemistry , stereochemistry , organic chemistry , computer science , biology , paleontology , programming language
Metallaphotoredox catalysis has evolved into an enabling platform to construct C(sp 3 )‐hybridized centers under remarkably mild reaction conditions. The cultivation of abundant radical precursor feedstocks has significantly increased the scope of transition‐metal‐catalyzed cross‐couplings, especially with respect to C(sp 2 )–C(sp 3 ) linkages. In recent years, considerable effort has been devoted to understanding the origin of stereoinduction in dual catalytic processes. In this context, Ni‐ and Cu‐catalyzed transformations have played a predominant role exploiting this mode of catalysis. Herein, we provide a critical overview on recent progress in enantioselective bond formations enabled by Ni‐ and Cu‐catalyzed manifolds. Furthermore, selected stereochemical control elements within the realm of diastereoselective transformations are discussed.