Premium
Four‐Dimensional Deoxyribonucleic Acid–Gold Nanoparticle Assemblies
Author(s) -
Luo Ming,
Xuan Mingjun,
Huo Shuaidong,
Fan Jilin,
Chakraborty Gurudas,
Wang Yixi,
Zhao Hui,
Herrmann Andreas,
Zheng Lifei
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202007616
Subject(s) - colloidal gold , nanorod , nanotechnology , dna , exonuclease iii , nanoparticle , materials science , dissipative particle dynamics , oligonucleotide , nanostructure , exonuclease , dissipative system , biophysics , chemistry , biology , physics , biochemistry , polymer , escherichia coli , quantum mechanics , dna polymerase , composite material , gene
Organization of gold nanoobjects by oligonucleotides has resulted in many three‐dimensional colloidal assemblies with diverse size, shape, and complexity; nonetheless, autonomous and temporal control during formation remains challenging. In contrast, living systems temporally and spatially self‐regulate formation of functional structures by internally orchestrating assembly and disassembly kinetics of dissipative biomacromolecular networks. We present a novel approach for fabricating four‐dimensional gold nanostructures by adding an additional dimension: time. The dissipative character of our system is achieved using exonuclease III digestion of deoxyribonucleic acid (DNA) fuel as an energy‐dissipating pathway. Temporal control over amorphous clusters composed of spherical gold nanoparticles (AuNPs) and well‐defined core–satellite structures from gold nanorods (AuNRs) and AuNPs is demonstrated. Furthermore, the high specificity of DNA hybridization allowed us to demonstrate selective activation of the evolution of multiple architectures of higher complexity in a single mixture containing small and larger spherical AuNPs and AuNRs.