Premium
Near‐Infrared Light‐Triggered Chlorine Radical ( . Cl) Stress for Cancer Therapy
Author(s) -
Song Ruixue,
Wang Han,
Zhang Meng,
Liu Yanyan,
Meng Xianfu,
Zhai Shaojie,
Wang Chaochao,
Gong Teng,
Wu Yelin,
Jiang Xingwu,
Bu Wenbo
Publication year - 2020
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.202007434
Subject(s) - radical , chlorine , reactive oxygen species , oxidizing agent , oxidative stress , chemistry , photochemistry , oxygen , nucleophile , cancer cell , cancer , biochemistry , organic chemistry , biology , catalysis , genetics
Free radicals with reactive chemical properties can fight tumors without causing drug resistance. Reactive oxygen species (ROS) has been widely used for cancer treatment, but regrettably, the common O 2 and H 2 O 2 deficiency in tumors sets a severe barrier for sufficient ROS production, leading to unsatisfactory anticancer outcomes. Here, we construct a chlorine radical ( . Cl) nano‐generator with SiO 2 ‐coated upconversion nanoparticles (UCNPs) on the inside and Ag 0 /AgCl hetero‐dots on the outside. Upon near‐infrared (NIR) light irradiation, the short‐wavelength emission UCNP catalyzes . Cl generation from Ag 0 /AgCl with no dependence on O 2 /H 2 O 2 . . Cl with strong oxidizing capacity and nucleophilicity can attack biomolecules in cancer cells more effectively than ROS. This . Cl stress treatment will no doubt broaden the family of oxidative stress‐induced antitumor strategies by using non‐oxygen free radicals, which is significant in the development of new anticancer agents.